AJMC
December 19, 2025

Report by Hayden E. Klein, fact-checked by Giuliana Grossi

Major Insights

  • The Inflation Reduction Act may lead to a rise in Medicare Part D restrictiveness, an increase in patient costs, and a decline in innovation, signaling the need for policy tweaks to balance cost containment and access.
  • Alterations in Federal policy including PBM reforms and the evolution of Medicaid/Medicare rules are transforming managed care pharmacy, demanding vigilant advocacy and monitoring.
  • Over 500 bills at the state level concentrate on PBM reform, 340B oversight, and AI regulations, with substantial federal changes like the Medicaid VBPs for Patients Act in the pipeline.
  • Despite setbacks from patent thickets and settlement agreements, the 2025 pharmaceutical pipeline grows with generics, biosimilars, and innovative therapies.
  • Demands for PBM transparency and reform underscore the need for collaboration among stakeholders to update practices, lower patient costs, and guarantee access.

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Topics:
Pharma,
Pharma / Biotech

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