FDA Approves Foundayo, an Obesity Medicine, with Significant Weight Loss Results in Trials
TL/DR –
Eli Lilly’s Foundayo, a pill taken orally for obesity treatment, has gained approval from the U.S. Food and Drug Administration. The pill has shown positive results in clinical trials with adults losing an average of 27 pounds on the highest dose. The medication, which can be taken with no food or water restrictions, will be available through LillyDirect with prescriptions starting from $25 per month with commercial coverage and $149 for self-pay.
Foundayo: New FDA-Approved Weight Loss Drug
The U.S. Food and Drug Administration (FDA) has approved Foundayo (orforglipron) as a new treatment for adults struggling with obesity or overweight with associated health issues. Manufactured by Eli Lilly and Company, this weight loss drug, when combined with a reduced-calorie diet and increased physical activity, helps to decrease and maintain a healthy body weight. Starting from April 2026, Foundayo will be available via LillyDirect, with accepted prescriptions shipped from April 6th onwards.
How Effective is Foundayo?
Deborah Horn, DO, director of the Center for Obesity Medicine at McGovern Medical School at UTHealth Houston, explained that Foundayo delivers an average of 12.4% weight loss at the highest dose in clinical trials. Backed by the comprehensive ATTAIN clinical trial program, Foundayo has been shown to help people not only lose weight but also keep it off. In the ATTAIN-1 trial, those on the highest dose who adhered to the treatment lost an average of 27.3 pounds (12.4%) in comparison to 2.2 pounds (0.9%) with placebo.
David A. Ricks, CEO of Eli Lilly, believes Foundayo can help combat obesity and overweight-related complications. As a once-daily oral pill that promotes meaningful weight loss, Foundayo offers a practical solution for those seeking a new approach to their weight loss journey. The drug will be available for as little as $25 per month with commercial insurance or $149 for self-pay options.
What are the Side Effects of Foundayo?
While the use of Foundayo with other GLP-1 receptor agonist medicines is not recommended, potential side effects can include nausea, constipation, diarrhea, vomiting, indigestion, abdominal pain, headache, swollen belly, tiredness, belching, heartburn, gas, and hair loss. More serious side effects could entail thyroid tumors or thyroid cancer. More information on the drug’s safety and potential side effects can be found in the Prescribing Information and Medication Guide.
Foundayo: A New Approach to Weight Loss
Joe Nadglowski, CEO of the Obesity Action Coalition, emphasized that new treatment options like Foundayo can provide individuals with a broader choice and help them find a weight loss strategy that suits them best. Lilly has submitted orforglipron for weight management and/or type 2 diabetes in over 40 countries, with plans to launch in each country following approval.
For more detailed information about Foundayo, please visit the official website.
About Foundayo
Foundayo is FDA-approved for adults with obesity or those overweight with related health problems. This daily pill helps to reduce excess body weight and maintain weight reduction long term, alongside a reduced-calorie diet and increased physical activity. Orforglipron, the active ingredient in Foundayo, was discovered by Chugai Pharmaceutical Co., Ltd. and licensed by Lilly in 2018. It is currently being studied as a potential treatment for type 2 diabetes, obstructive sleep apnea, osteoarthritis knee pain, hypertension, peripheral artery disease, and stress urinary incontinence.
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